Several studies have demonstrated hypoglycemic properties of fenugreek (Trigonella foenum-graecum L.) seeds both in animals and humans. The seeds contain fiber, 4-hydroxyisoleucine and diosgenine, components that may possess hypoglycemic activity. The mechanism is thought to be based both on mechanical dynamics (delay of gastric emptying and slowing down of carbohydrate absorption) and on a insulinotropic model, via receptors. Fenugreek also increases the number of insulin receptors in red blood cells and improves glucose utilization in peripheral tissues, beside having an antidyslipidemic activity.

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